Pharmaceutical Giant Pfizer Begins Manufacturing Hundreds of Thousands of Doses of COVID-19 Vaccine

Pfizer | October 19, 2020

US pharmaceutical giant Pfizer has begun manufacturing hundreds of thousands of doses of its COVID-19 vaccine ahead of its expected approval next month. The UK’s Daily Mail on Sunday published video showing a manufacturing plant in Puurs, Belgium with thousands of doses of the vaccine coming off the production line.

Pfizer said last week it expects to file for emergency use authorization for its COVID-19 vaccine in late November, around two weeks after the November 3 US presidential election. The company said it hopes to move ahead with the vaccine after safety data is available in the third week of November.

The company has said it hopes to make 100 million doses available this year and a massive 1,3 billion available in 2021. Each recipient will need two doses.

“It was great to see the first vial coming off the manufacturing line,” Pfizer UK head Ben Osborn told the Daily Mail. “It just brought a tremendous smile to my face to see all of this work actually result in a product.”

In July the US announced it will pay Pfizer nearly $2 billion for a December delivery of 100 million doses of a COVID-19 vaccine the pharmaceutical company is developing. The US could buy another 500 million doses under the agreement.

The agreement is part of US President Donald Trump’s Operation Warp Speed vaccine program, under which multiple COVID-19 vaccines are being developed simultaneously. The program aims to deliver 300 million doses of a safe and effective COVID-19 vaccine by January 2021.

Under the initiative, the government will speed development and buy vaccines — before they are deemed safe and effective — so that the medication can be in hand and quickly distributed once the FDA approves or authorizes its emergency use after clinical trials.

The Pfizer announcement last week means the United States could have two vaccines ready by the end of the year, with Massachusetts biotech firm Moderna aiming for November 25 to seek authorization. The Food and Drug Administration (FDA), which authorizes pharmaceuticals for distribution in the US — asked vaccine developers last week to spend two months monitoring for serious side effects after the second dose is given to trial participants.

The FDA will require the vaccine to prove effective and safe, while Pfizer will have to demonstrate it is capable of producing large scale production. Pfizer and Modern, both funded by the US government, launched Phase 3 of their clinical trials at the end of July, and both have started production of doses.

Spotlight

The 3D printing industry is exploding. With all the new developments, it’s sometimes hard to remember where 3D printing started. In this infographic, T. Rowe Price gives us all a little perspective on just how far this industry has come since stereolithography was created in 1984.

Spotlight

The 3D printing industry is exploding. With all the new developments, it’s sometimes hard to remember where 3D printing started. In this infographic, T. Rowe Price gives us all a little perspective on just how far this industry has come since stereolithography was created in 1984.

Related News

3D PRINTING

Velo3D Approves New Superalloy for Use in its Sapphire® Printer Family

Velo3D | January 07, 2022

Velo3D, Inc., a leader in metal additive manufacturing technology for mission-critical parts, has qualified Amperprint® 0233 Haynes® 282®, a nickel-based superalloy powder, for use in its Sapphire® line of printers. The powder was manufactured under license from Haynes International, Inc. by Höganäs AB, a world leader in metal powder production. It is developed for high creep strength, thermal stability, weldability, and fabricability not found in other alloys. As a result, the material is well suited for high-temperature structural applications such as energy generation, gas turbines, and space launch vehicles. In addition, it is used to construct heat exchangers, combustors, nozzles, combustion liners, rocket engines, and shrouded impellers. Duncan Machine Products (DMP), a contract manufacturer situated in Duncan, Oklahoma, will run the first Sapphire® printer using Amperprint® 0233 and Haynes® 282® powder. The system will be DMP's eighth Velo3D Sapphire® printer. "Our goal at Velo3D is to enable engineers to build the parts they want without compromising on design or quality, Qualifying new powdered metals, like Amperprint® 0233 and Haynes® 282®, for use in our end-to-end solution further expands what’s possible with our additive manufacturing technology. Our partners at Höganäs provide materials of the highest quality, and I look forward to seeing what our customers build using this amazing alloy." -Benny Buller, Velo3D CEO and Founder. For high-temperature applications, powdered nickel-based superalloys, such as Amperprint 0233 and Haynes® 282®, are typically used to print parts because of the alloy's resilience to cracking and its ability to work at temperatures close to the melting point. This tolerance enables the alloy-printed components to be used in vacuums, plasmas, and other demanding environments. In addition, due to the powder's excellent weldability, it is useful for components in bigger systems due to its ability to be welded to other components. Höganäs is a leader in developing powders for additive manufacturing, producing products with a uniform spherical shape, precise chemical control, and better flowability. The powders are created from the purest sources and have exact trace element compositions that give the metals their distinctive qualities. "It’s inspiring to see what engineers have been able to build using metal powders from Höganäs and Velo3D’s support-free additive manufacturing process,The first parts printed using our Amperprint® 0233 Haynes® 282® powder are impressive, and I believe customers are only scratching the surface of what is possible with this superalloy. The powder, combined with Velo3D’s end-to-end solution metal AM solution, is an extremely effective combination for consolidating parts into monolithic structures to eliminate coefficient of thermal expansion in large, high-performance systems." -Jerome Stanley, Höganäs Director of Global Sales, Customization Technologies. Velo3D was one of the first companies to offer Amperprint® 0233 Haynes® 282® powder to its customers. Many of Velo3D's customers use the company's end-to-end solution to manufacture components for aviation, energy, oil and gas, space, and other high-performance applications, making the powder a natural fit for the company's portfolio. Along with Amperprint® 0233, Haynes® 282® powder, Velo3D's technology is compatible with the following metal powders: Hastelloy X®, Inconel 718, aluminum F357, Ti 6Al-4V Grade 5, and several more. *This press release contains "forward-looking statements" as defined by the Private Securities Litigation Reform Act of 1996. These forward-looking statements include, but are not limited to, statements about the company's future expectations, hopes, beliefs, intentions, or strategies. They contain significant risks and uncertainties that could cause actual results to differ materially from those anticipated. Accordingly, you should carefully evaluate the risks and uncertainties outlined in the company's periodic SEC filings.

Read More

Delta Electronics Acquires Trihedral to Help Facilitate a Broader Business in Digitized Manufacturing

Delta Electronics | November 05, 2020

Delta, a global leader in power and thermal management solutions, today announced it has closed the acquisition of Trihedral Engineering Limited, a SCADA and IIoT software company based in Canada. Under the terms of the agreement, Delta Electronics (Netherlands) B.V., a wholly-owned subsidiary of Delta, acquired 100% of Trihedral's interests. The acquisition represents a key part of Delta's long-term strategy in its industrial automation and system integration portfolios – and is expected to help facilitate a broader business in digitized manufacturing. Delta plans to use its existing global sales and service network to expand Trihedral's signature VTScada software solution globally. Integrating Delta hardware and Trihedral software will allow both to play on their strengths in the rapidly growing fields of Automation, AI and Data Analytics. "Together, Delta and Trihedral will foster significant synergies – adding value both for our employees and customers worldwide," said Simon Chang, president and COO of Delta Electronics, Inc. "Trihedral's leadership in SCADA software development will bring considerable benefits for our organization, as we focus on smart manufacturing, smart building and smart micro-grid solutions." Trihedral will keep both its namesake brand and management team. Delta will leverage Trihedral's expertise in a range of field applications and industries, including water treatment, oil and gas, among others. Founded in 1986, Trihedral serves customers in more than 100 countries. Its proprietary VTScada software is widely used in large power, water treatment and other mission critical infrastructure installations across North America.

Read More

MANUFACTURING TECHNOLOGY

Desktop Metal Triples Manufacturing Capacity for Production System P-50

Desktop Metal | November 02, 2021

Desktop Metal today announced the opening of a new in-house manufacturing facility that will more than triple the final assembly space currently dedicated to the Production SystemTM platform to meet robust demand for the world’s fastest metal 3D printing technology. This new facility is part of a strategic plan to accelerate the production ramp of Desktop Metal’s flagship Production System P-50 printer, for which the Company is engaged in component procurement and assembly of initial builds targeted for shipment in the fourth quarter of 2021. “After a significant development cycle, we are experiencing growing, pent-up demand for our Production System P-50 solution. As we continue to convert these opportunities, expanding our in-house final assembly capabilities has become a critical step to scaling deployment of our Single Pass Jetting technology,This new facility in Massachusetts, in conjunction with our contract manufacturers and suppliers, supports our ability to meet growing demand for high-volume applications. We are now well-positioned to supply our global customers with the fastest metal 3D printing platform to enable cost-effective mass production via additive manufacturing.” Ric Fulop, Founder and CEO of Desktop Metal Created by the inventors of binder jetting and single-pass inkjet technology, the Production System is an industrial manufacturing platform powered by Desktop Metal’s Single Pass JettingTM technology. It is designed to achieve speeds up to 100 times those of legacy powder bed fusion additive manufacturing technologies and enable production quantities of up to millions of parts per year at costs competitive with conventional mass production techniques. The P-50 printer is paving the way for the mass production of end-use parts -- unlocking throughput, repeatability, and competitive part costs. For more information on the P-1, the P-50, and Production System technology, visit www.desktopmetal.com/products/production. About Desktop Metal Desktop Metal, Inc., based in Burlington, Massachusetts, is accelerating the transformation of manufacturing with an expansive portfolio of 3D printing solutions, from rapid prototyping to mass production. Founded in 2015 by leaders in advanced manufacturing, metallurgy, and robotics, the company is addressing the unmet challenges of speed, cost, and quality to make additive manufacturing an essential tool for engineers and manufacturers around the world. Desktop Metal was selected as one of the world’s 30 most promising Technology Pioneers by the World Economic Forum, named to MIT Technology Review’s list of 50 Smartest Companies. For more information, visit www.desktopmetal.com.

Read More